Ontology highlight
ABSTRACT:
SUBMITTER: Rink JC
PROVIDER: S-EPMC2861735 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Rink Jochen C JC Gurley Kyle A KA Elliott Sarah A SA Sánchez Alvarado Alejandro A
Science (New York, N.Y.) 20091022 5958
The Hedgehog (Hh) signaling pathway plays multiple essential roles during metazoan development, homeostasis, and disease. Although core protein components are highly conserved, the variations in Hh signal transduction mechanisms exhibited by existing model systems (Drosophila, fish, and mammals) are difficult to understand. We characterized the Hh pathway in planarians. Hh signaling is essential for establishing the anterior/posterior axis during regeneration by modulating wnt expression. Moreov ...[more]