Ontology highlight
ABSTRACT:
SUBMITTER: Billingsley K
PROVIDER: S-EPMC2862111 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Billingsley Kelvin K Balaconis Mary K MK Dubach J Matthew JM Zhang Ning N Lim Ed E Francis Kevin P KP Clark Heather A HA
Analytical chemistry 20100501 9
We have designed fluorescent nanosensors based on ion-selective optodes capable of detecting small molecules. By localizing the sensor components in a hydrophobic core, these nanosensors are able to monitor dynamic changes in concentration of the model analyte, glucose. The nanosensors demonstrated this response in vitro and also when injected subcutaneously into mice. The response of the nanosensors tracked changes in blood glucose levels in vivo that were comparable to measurements taken using ...[more]