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Fluorescent nano-optodes for glucose detection.

ABSTRACT: We have designed fluorescent nanosensors based on ion-selective optodes capable of detecting small molecules. By localizing the sensor components in a hydrophobic core, these nanosensors are able to monitor dynamic changes in concentration of the model analyte, glucose. The nanosensors demonstrated this response in vitro and also when injected subcutaneously into mice. The response of the nanosensors tracked changes in blood glucose levels in vivo that were comparable to measurements taken using a glucometer. The development of these nanosensors offers an alternative, minimally invasive tool for monitoring glucose levels in such fields as diabetes research. Furthermore, the extension of the ion-selective optode sensor platform to small molecule detection will allow for enhanced monitoring of physiological processes.

SUBMITTER: Billingsley K

PROVIDER: S-EPMC2862111 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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Fluorescent nano-optodes for glucose detection.

Billingsley Kelvin K Balaconis Mary K MK Dubach J Matthew JM Zhang Ning N Lim Ed E Francis Kevin P KP Clark Heather A HA

Analytical chemistry 20100501 9

We have designed fluorescent nanosensors based on ion-selective optodes capable of detecting small molecules. By localizing the sensor components in a hydrophobic core, these nanosensors are able to monitor dynamic changes in concentration of the model analyte, glucose. The nanosensors demonstrated this response in vitro and also when injected subcutaneously into mice. The response of the nanosensors tracked changes in blood glucose levels in vivo that were comparable to measurements taken using ...[more]

PMID: 20355725

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