Ontology highlight
ABSTRACT:
SUBMITTER: Drinjakovic J
PROVIDER: S-EPMC2862300 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Drinjakovic Jovana J Jung Hosung H Campbell Douglas S DS Strochlic Laure L Dwivedy Asha A Holt Christine E CE
Neuron 20100201 3
Regulated protein degradation via the ubiquitin-proteasome system (UPS) plays a central role in building synaptic connections, yet little is known about either which specific UPS components are involved or UPS targets in neurons. We report that inhibiting the UPS in developing Xenopus retinal ganglion cells (RGCs) with a dominant-negative ubiquitin mutant decreases terminal branching in the tectum but does not affect long-range navigation to the tectum. We identify Nedd4 as a prominently express ...[more]