Bioactive constituents of the stem bark of Mitrephora glabra.
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ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC2862477 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
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Bioactive constituents of the stem bark of Mitrephora glabra.
Li Chen C Lee Dongho D Graf Tyler N TN Phifer Sharnelle S SS Nakanishi Yuka Y Riswan Soedarsono S Setyowati Fransisca M FM Saribi Achmad M AM Soejarto Djaja D DD Farnsworth Norman R NR Falkinham Joseph O JO Kroll David J DJ Kinghorn A Douglas AD Wani Mansukh C MC Oberlies Nicholas H NH
Journal of natural products 20091101 11
Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms. ...[more]
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