Ontology highlight
ABSTRACT:
SUBMITTER: Renthal R
PROVIDER: S-EPMC2862650 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Cellular and molecular life sciences : CMLS 20091229 7
Polytopic alpha-helical membrane proteins cannot spontaneously insert into lipid bilayers without assistance from polytopic alpha-helical membrane proteins that already reside in the membrane. This raises the question of how these proteins evolved. Our current knowledge of the insertion of alpha-helices into natural and model membranes is reviewed with the goal of gaining insight into the evolution of membrane proteins. Topics include: translocon-dependent membrane protein insertion, antibiotic ...[more]