Ontology highlight
ABSTRACT:
SUBMITTER: Jonsson AH
PROVIDER: S-EPMC2862662 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20100301 7
NK cells are innate immune lymphocytes that can react to cells lacking self-MHC class I. However, NK cells that cannot engage self-MHC through an inhibitory receptor are resistant to stimulation through their activation receptors. To become licensed (i.e., functionally competent to be triggered through its activation receptors), an NK cell must engage host MHC class I via a MHC class I-specific inhibitory receptor, such as a member of the murine Ly49 family. To explore potential determinants of ...[more]