Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Techera A
PROVIDER: S-EPMC2863005 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
González-Techera A A Umpiérrez-Failache M M Cardozo S S Obal G G Pritsch O O Last J A JA Gee S J SJ Hammock B D BD González-Sapienza G G
Bioconjugate chemistry 20080405 5
The use of phage display peptide libraries allows rapid isolation of peptide ligands for any target selector molecule. However, due to differences in peptide expression and the heterogeneity of the phage preparations, there is no easy way to compare the binding properties of the selected clones, which operates as a major "bottleneck" of the technology. Here, we present the development of a new type of library that allows rapid comparison of the relative affinity of the selected peptides in a hig ...[more]