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SprB is the molecular link between Salmonella pathogenicity island 1 (SPI1) and SPI4.


ABSTRACT: Salmonella pathogenicity island 1 (SPI1) and SPI4 have previously been shown to be jointly regulated. We report that SPI1 and SPI4 gene expression is linked through a transcriptional activator, SprB, encoded within SPI1 and regulated by HilA. SprB directly activates SPI4 gene expression and weakly represses SPI1 gene expression through HilD.

SUBMITTER: Saini S 

PROVIDER: S-EPMC2863475 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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SprB is the molecular link between Salmonella pathogenicity island 1 (SPI1) and SPI4.

Saini Supreet S   Rao Christopher V CV  

Journal of bacteriology 20100226 9


Salmonella pathogenicity island 1 (SPI1) and SPI4 have previously been shown to be jointly regulated. We report that SPI1 and SPI4 gene expression is linked through a transcriptional activator, SprB, encoded within SPI1 and regulated by HilA. SprB directly activates SPI4 gene expression and weakly represses SPI1 gene expression through HilD. ...[more]

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