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Novel FKS mutations associated with echinocandin resistance in Candida species.

ABSTRACT: We studied three clinical isolates of Candida spp. (one C. tropicalis isolate and two C. glabrata isolates) from patients with invasive candidiasis. The first isolate emerged during echinocandin treatment, while the others emerged after the same treatment. These strains harbored an amino acid substitution in Fksp never linked before with reduced echinocandin susceptibility in C. tropicalis or in C. glabrata. The molecular mechanism of reduced susceptibility was confirmed using a 1,3-beta-D-glucan synthase inhibition assay.

SUBMITTER: Garcia-Effron G

PROVIDER: S-EPMC2863628 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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Novel FKS mutations associated with echinocandin resistance in Candida species.

Garcia-Effron Guillermo G Chua Daniel Joseph DJ Tomada Jon Rupert JR DiPersio Joseph J Perlin David S DS Ghannoum Mahmoud M Bonilla Hector H

Antimicrobial agents and chemotherapy 20100209 5

We studied three clinical isolates of Candida spp. (one C. tropicalis isolate and two C. glabrata isolates) from patients with invasive candidiasis. The first isolate emerged during echinocandin treatment, while the others emerged after the same treatment. These strains harbored an amino acid substitution in Fksp never linked before with reduced echinocandin susceptibility in C. tropicalis or in C. glabrata. The molecular mechanism of reduced susceptibility was confirmed using a 1,3-beta-D-gluca ...[more]

PMID: 20145084

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