Ontology highlight
ABSTRACT:
SUBMITTER: Mui MZ
PROVIDER: S-EPMC2863776 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Mui Melissa Z MZ Roopchand Diana E DE Gentry Matthew S MS Hallberg Richard L RL Vogel Jackie J Branton Philip E PE
Journal of virology 20100217 9
Protein phosphatase 2A (PP2A) has been implicated in cell cycle progression and mitosis; however, the complexity of PP2A regulation via multiple B subunits makes its functional characterization a significant challenge. The human adenovirus protein E4orf4 has been found to induce both high Cdk1 activity and the accumulation of cells in G(2)/M in both mammalian and yeast cells, effects which are largely dependent on the B55/Cdc55 regulatory subunit of PP2A. Thus, E4orf4 represents a unique means b ...[more]