Ontology highlight
ABSTRACT:
SUBMITTER: Shankaran H
PROVIDER: S-EPMC2864016 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Shankaran Harish H Zhang Yi Y Opresko Lee L Resat Haluk H
Biochemical and biophysical research communications 20080418 2
The human epidermal growth factor receptor (HER) system is an intricately regulated system that plays critical roles in development and tumorigenesis. Here, we apply integrated experimentation and modeling to analyze HER receptor activation in a panel of cell lines expressing endogenous levels of EGFR/HER1 and different levels of HER2. A mathematical model that includes the fundamental processes involved in receptor activation and trafficking was used to fit the experimental data, and values of ...[more]