Ontology highlight
ABSTRACT:
SUBMITTER: Kelley DR
PROVIDER: S-EPMC2864568 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Kelley David R DR Salzberg Steven L SL
Genome biology 20100310 3
Diploid genomes with divergent chromosomes present special problems for assembly software as two copies of especially polymorphic regions may be mistakenly constructed, creating the appearance of a recent segmental duplication. We developed a method for identifying such false duplications and applied it to four vertebrate genomes. For each genome, we corrected mis-assemblies, improved estimates of the amount of duplicated sequence, and recovered polymorphisms between the sequenced chromosomes. ...[more]