Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action.
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ABSTRACT:
SUBMITTER: Hillenmeyer ME
PROVIDER: S-EPMC2864570 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
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Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action.
Hillenmeyer Maureen E ME Ericson Elke E Davis Ronald W RW Nislow Corey C Koller Daphne D Giaever Guri G
Genome biology 20100312 3
We systematically analyzed the relationships between gene fitness profiles (co-fitness) and drug inhibition profiles (co-inhibition) from several hundred chemogenomic screens in yeast. Co-fitness predicted gene functions distinct from those derived from other assays and identified conditionally dependent protein complexes. Co-inhibitory compounds were weakly correlated by structure and therapeutic class. We developed an algorithm predicting protein targets of chemical compounds and verified its ...[more]
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