Ontology highlight
ABSTRACT:
SUBMITTER: Zorrilla EP
PROVIDER: S-EPMC2864802 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Zorrilla Eric P EP Koob George F GF
Drug discovery today 20100303 9-10
Corticotropin releasing factor (CRF) receptor antagonists have been sought since the stress-secreted peptide was isolated in 1981. Although evidence is mixed concerning the efficacy of CRF(1) antagonists as antidepressants, CRF(1) antagonists might be novel pharmacotherapies for anxiety and addiction. Progress in understanding the two-domain model of ligand-receptor interactions for CRF family receptors might yield chemically novel CRF(1) receptor antagonists, including peptide CRF(1) antagonist ...[more]