Ontology highlight
ABSTRACT:
SUBMITTER: Gartmann M
PROVIDER: S-EPMC2865328 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Gartmann Marco M Blau Michael M Armache Jean-Paul JP Mielke Thorsten T Topf Maya M Beckmann Roland R
The Journal of biological chemistry 20100331 20
During the process of ribosomal assembly, the essential eukaryotic translation initiation factor 6 (eIF6) is known to act as a ribosomal anti-association factor. However, a molecular understanding of the anti-association activity of eIF6 is still missing. Here we present the cryo-electron microscopy reconstruction of a complex of the large ribosomal subunit with eukaryotic eIF6 from Saccharomyces cerevisiae. The structure reveals that the eIF6 binding site involves mainly rpL23 (L14p in Escheric ...[more]