Ontology highlight
ABSTRACT:
SUBMITTER: Kihira Y
PROVIDER: S-EPMC2865335 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Kihira Yoshitaka Y Hermanstyne Tracey O TO Misonou Hiroaki H
The Journal of biological chemistry 20100304 20
The formation of heteromeric tetramers is a common feature of voltage-gated potassium (Kv) channels. This results in the generation of a variety of tetrameric Kv channels that exhibit distinct biophysical and biochemical characteristics. Kv2 delayed rectifier channels are, however, unique exceptions. It has been previously shown that mammalian Kv2.1 and Kv2.2 are localized in distinct domains of neuronal membranes and are not capable of forming heteromeric channels with each other (Hwang, P. M., ...[more]