Ontology highlight
ABSTRACT:
SUBMITTER: Putnam CD
PROVIDER: S-EPMC2865514 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Putnam Christopher D CD Hayes Tikvah K TK Kolodner Richard D RD
PLoS genetics 20100506 5
RAD6 is known to suppress duplication-mediated gross chromosomal rearrangements (GCRs) but not single-copy sequence mediated GCRs. Here, we found that the RAD6- and RAD18-dependent post-replication repair (PRR) and the RAD5-, MMS2-, UBC13-dependent error-free PRR branch acted in concert with the replication stress checkpoint to suppress duplication-mediated GCRs formed by homologous recombination (HR). The Rad5 helicase activity, but not its RING finger, was required to prevent duplication-media ...[more]