A differentiation-based phylogeny of cancer subtypes.
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ABSTRACT:
SUBMITTER: Riester M
PROVIDER: S-EPMC2865519 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
A differentiation-based phylogeny of cancer subtypes.
Riester Markus M Stephan-Otto Attolini Camille C Downey Robert J RJ Singer Samuel S Michor Franziska F
PLoS computational biology 20100506 5
Histopathological classification of human tumors relies in part on the degree of differentiation of the tumor sample. To date, there is no objective systematic method to categorize tumor subtypes by maturation. In this paper, we introduce a novel computational algorithm to rank tumor subtypes according to the dissimilarity of their gene expression from that of stem cells and fully differentiated tissue, and thereby construct a phylogenetic tree of cancer. We validate our methodology with express ...[more]
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