Ontology highlight
ABSTRACT:
SUBMITTER: Hideshima T
PROVIDER: S-EPMC2865869 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Hideshima Teru T Mitsiades Constantine C Ikeda Hiroshi H Chauhan Dharminder D Raje Noopur N Gorgun Gullu G Hideshima Hiromasa H Munshi Nikhil C NC Richardson Paul G PG Carrasco Daniel R DR Anderson Kenneth C KC
Blood 20100312 18
Constitutive B-cell lymphoma 6 (Bcl-6) expression was undetectable in multiple myeloma (MM) cell lines, except U266 cells. However, it was up-regulated by coculture with bone marrow (BM) stromal cell-culture supernatant (SCCS). Bcl-6 expression in patient MM cells in the BM was positive. Anti-interleukin-6 (IL-6)-neutralizing antibody significantly blocked SCCS-induced Bcl-6 in MM cells. Indeed, IL-6 strongly triggered Bcl-6 expression in MM cells, whereas Janus kinase inhibitor and STAT3 siRNA ...[more]