Functional amyloids as natural storage of peptide hormones in pituitary secretory granules.
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ABSTRACT:
SUBMITTER: Maji SK
PROVIDER: S-EPMC2865899 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Functional amyloids as natural storage of peptide hormones in pituitary secretory granules.
Maji Samir K SK Perrin Marilyn H MH Sawaya Michael R MR Jessberger Sebastian S Vadodaria Krishna K Rissman Robert A RA Singru Praful S PS Nilsson K Peter R KP Simon Rozalyn R Schubert David D Eisenberg David D Rivier Jean J Sawchenko Paul P Vale Wylie W Riek Roland R
Science (New York, N.Y.) 20090618 5938
Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are store ...[more]
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