Ontology highlight
ABSTRACT:
SUBMITTER: Arenas M
PROVIDER: S-EPMC2865913 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Arenas Miguel M Posada David D
Genetics 20100201 4
While a variety of methods exist to reconstruct ancestral sequences, all of them assume that a single phylogeny underlies all the positions in the alignment and therefore that recombination has not taken place. Using computer simulations we show that recombination can severely bias ancestral sequence reconstruction (ASR), and quantify this effect. If recombination is ignored, the ancestral sequences recovered can be quite distinct from the grand most recent common ancestor (GMRCA) of the sample ...[more]