Ontology highlight
ABSTRACT:
SUBMITTER: Shigetomi E
PROVIDER: S-EPMC2866443 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Shigetomi Eiji E Bowser David N DN Sofroniew Michael V MV Khakh Baljit S BS
The Journal of neuroscience : the official journal of the Society for Neuroscience 20080601 26
Astrocytes display excitability in the form of intracellular calcium concentration ([Ca(2+)](i)) increases, but the signaling impact of these for neurons remains debated and controversial. A key unresolved issue is whether astrocyte [Ca(2+)](i) elevations impact neurons or not. Here we report that in the CA1 region of the hippocampus, agonists of native P2Y(1) and PAR-1 receptors, which are preferentially expressed in astrocytes, equally elevated [Ca(2+)](i) levels without affecting the passive ...[more]