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The small heat shock protein, HSPB6, in muscle function and disease.

ABSTRACT: The small heat shock protein, HSPB6, is a 17-kDa protein that belongs to the small heat shock protein family. HSPB6 was identified in the mid-1990s when it was recognized as a by-product of the purification of HSPB1 and HSPB5. HSPB6 is highly and constitutively expressed in smooth, cardiac, and skeletal muscle and plays a role in muscle function. This review will focus on the physiologic and biochemical properties of HSPB6 in smooth, cardiac, and skeletal muscle; the putative mechanisms of action; and therapeutic implications.

SUBMITTER: Dreiza CM 

PROVIDER: S-EPMC2866971 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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The small heat shock protein, HSPB6, in muscle function and disease.

Dreiza Catherine M CM   Komalavilas Padmini P   Furnish Elizabeth J EJ   Flynn Charles R CR   Sheller Michael R MR   Smoke Christopher C CC   Lopes Luciana B LB   Brophy Colleen M CM  

Cell stress & chaperones 20090701 1

The small heat shock protein, HSPB6, is a 17-kDa protein that belongs to the small heat shock protein family. HSPB6 was identified in the mid-1990s when it was recognized as a by-product of the purification of HSPB1 and HSPB5. HSPB6 is highly and constitutively expressed in smooth, cardiac, and skeletal muscle and plays a role in muscle function. This review will focus on the physiologic and biochemical properties of HSPB6 in smooth, cardiac, and skeletal muscle; the putative mechanisms of actio  ...[more]

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