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Enzymatic activation of a matrix metalloproteinase inhibitor.

ABSTRACT: Matrix metalloproteinase inhibitors (MMPi) possessing a glucose protecting group on the zinc-binding group (ZBG) show a dramatic increase in inhibitory activity upon cleavage by beta-glucosidase.

SUBMITTER: Major Jourden JL 

PROVIDER: S-EPMC2867072 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Enzymatic activation of a matrix metalloproteinase inhibitor.

Major Jourden Jody L JL   Cohen Seth M SM  

Chemical communications (Cambridge, England) 20100118 8

Matrix metalloproteinase inhibitors (MMPi) possessing a glucose protecting group on the zinc-binding group (ZBG) show a dramatic increase in inhibitory activity upon cleavage by beta-glucosidase. ...[more]

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