Ontology highlight
ABSTRACT:
SUBMITTER: Filimonenko M
PROVIDER: S-EPMC2867245 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Filimonenko Maria M Isakson Pauline P Finley Kim D KD Anderson Monique M Jeong Hyun H Melia Thomas J TJ Bartlett Bryan J BJ Myers Katherine M KM Birkeland Hanne C G HC Lamark Trond T Krainc Dimitri D Brech Andreas A Stenmark Harald H Simonsen Anne A Yamamoto Ai A
Molecular cell 20100401 2
There is growing evidence that macroautophagic cargo is not limited to bulk cytosol in response to starvation and can occur selectively for substrates, including aggregated proteins. It remains unclear, however, whether starvation-induced and selective macroautophagy share identical adaptor molecules to capture their cargo. Here, we report that Alfy, a phosphatidylinositol 3-phosphate-binding protein, is central to the selective elimination of aggregated proteins. We report that the loss of Alfy ...[more]