Ontology highlight
ABSTRACT:
SUBMITTER: Astronomo RD
PROVIDER: S-EPMC2867452 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Astronomo Rena D RD Kaltgrad Eiton E Udit Andrew K AK Wang Sheng-Kai SK Doores Katie J KJ Huang Cheng-Yuan CY Pantophlet Ralph R Paulson James C JC Wong Chi-Huey CH Finn M G MG Burton Dennis R DR
Chemistry & biology 20100401 4
The broadly neutralizing antibody 2G12 recognizes a conserved cluster of high-mannose glycans on the surface envelope spike of HIV, suggesting that the "glycan shield" defense of the virus can be breached and may, under the right circumstances, serve as a vaccine target. In an attempt to recreate features of the glycan shield semisynthetically, oligomannosides were coupled to surface lysines on the icosahedral capsids of bacteriophage Q beta and cowpea mosaic virus (CPMV). The Q beta glycoconjug ...[more]