Ontology highlight
ABSTRACT:
SUBMITTER: Gilmore RD
PROVIDER: S-EPMC2867675 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Gilmore Robert D RD Howison Rebekah R RR Dietrich Gabrielle G Patton Toni G TG Clifton Dawn R DR Carroll James A JA
Proceedings of the National Academy of Sciences of the United States of America 20100405 16
The spirochetal agent of Lyme disease, Borrelia burgdorferi, is transmitted by bites of Ixodes ticks to mammalian reservoir hosts and humans. The mechanism(s) by which the organism is trafficked from vector to host is poorly understood. In this study, we demonstrate that a B. burgdorferi mutant strain deficient in the synthesis of the bba64 gene product was incapable of infecting mice via tick bite even though the mutant was (i) infectious in mice when introduced by needle inoculation, (ii) acqu ...[more]