Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts.
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ABSTRACT:
SUBMITTER: Bassett JH
PROVIDER: S-EPMC2867713 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
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Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts.
Bassett J H Duncan JH Boyde Alan A Howell Peter G T PG Bassett Richard H RH Galliford Thomas M TM Archanco Marta M Evans Holly H Lawson Michelle A MA Croucher Peter P St Germain Donald L DL Galton Valerie Anne VA Williams Graham R GR
Proceedings of the National Academy of Sciences of the United States of America 20100405 16
Hypothyroidism and thyrotoxicosis are each associated with an increased risk of fracture. Although thyroxine (T4) is the predominant circulating thyroid hormone, target cell responses are determined by local intracellular availability of the active hormone 3,5,3'-L-triiodothyronine (T3), which is generated from T4 by the type 2 deiodinase enzyme (D2). To investigate the role of locally produced T3 in bone, we characterized mice deficient in D2 (D2KO) in which the serum T3 level is normal. Bones ...[more]
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