Ontology highlight
ABSTRACT:
SUBMITTER: Hawkins RD
PROVIDER: S-EPMC2867844 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Cell stem cell 20100501 5
Human embryonic stem cells (hESCs) share an identical genome with lineage-committed cells, yet possess the remarkable properties of self-renewal and pluripotency. The diverse cellular properties in different cells have been attributed to their distinct epigenomes, but how much epigenomes differ remains unclear. Here, we report that epigenomic landscapes in hESCs and lineage-committed cells are drastically different. By comparing the chromatin-modification profiles and DNA methylomes in hESCs and ...[more]