Ontology highlight
ABSTRACT:
SUBMITTER: Willcocks LC
PROVIDER: S-EPMC2867866 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Willcocks Lisa C LC Carr Edward J EJ Niederer Heather A HA Rayner Tim F TF Williams Thomas N TN Yang Wanling W Scott J Anthony G JA Urban Britta C BC Peshu Norbert N Vyse Timothy J TJ Lau Yu Lung YL Lyons Paul A PA Smith Kenneth G C KG
Proceedings of the National Academy of Sciences of the United States of America 20100412 17
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease more prevalent in people of African and Asian origin than Caucasian origin. FcgammaRIIb is an inhibitory Fc receptor with a critical role in immune regulation. Mouse data suggest that FcgammaRIIb deficiency increases susceptibility to autoimmune disease but protects against infection. We show that a SNP in human FCGR2B that abrogates receptor function is strongly associated with susceptibility to SLE in both Caucasians and So ...[more]