Pathways: Strategies for susceptibility genes in SLE.
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ABSTRACT:
SUBMITTER: Kelley JM
PROVIDER: S-EPMC2868085 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Pathways: Strategies for susceptibility genes in SLE.
Kelley James M JM Edberg Jeffrey C JC Kimberly Robert P RP
Autoimmunity reviews 20100208 7
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder marked by an inappropriate immune response to nuclear antigens. Recent whole genome association and more focused studies have revealed numerous genes implicated in this disease process, including ITGAM, Fc gamma receptors, complement components, C-reactive protein, and others. One common feature of these molecules is their involvement in the immune opsonin pathway and in phagocytic clearing of nuclear antigens and apoptotic debr ...[more]
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