Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC2869382 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Li Xia X Du Yunrui Y Siegel Steven S Siegel Steven S Ferro-Novick Susan S Novick Peter P
Molecular biology of the cell 20100331 10
Inheritance of the endoplasmic reticulum (ER) requires Ptc1p, a type 2C protein phosphatase of Saccharomyces cerevisiae. Genetic analysis indicates that Ptc1p is needed to inactivate the cell wall integrity (CWI) MAP kinase, Slt2p. Here we show that under normal growth conditions, Ptc1p inactivates Slt2p just as ER tubules begin to spread from the bud tip along the cortex. In ptc1Delta cells, the propagation of cortical ER from the bud tip to the periphery of the bud is delayed by hyperactivatio ...[more]