Ontology highlight
ABSTRACT:
SUBMITTER: Chopra SS
PROVIDER: S-EPMC2869449 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Chopra Sameer S SS Stroud Dina Myers DM Watanabe Hiroshi H Bennett Jeffrey S JS Burns C Geoffrey CG Wells K Sam KS Yang Tao T Zhong Tao P TP Roden Dan M DM
Circulation research 20100325 8
<h4>Rationale</h4>Voltage-gated sodium channels initiate action potentials in excitable tissues. Mice in which Scn5A (the predominant sodium channel gene in heart) has been knocked out die early in development with cardiac malformations by mechanisms which have yet to be determined.<h4>Objective</h4>Here we addressed this question by investigating the role of cardiac sodium channels in zebrafish heart development.<h4>Methods and results</h4>Transcripts of the functionally-conserved Scn5a homolog ...[more]