Ontology highlight
ABSTRACT:
SUBMITTER: Vander Kooi CW
PROVIDER: S-EPMC2871033 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Vander Kooi Craig W CW Ren Liping L Xu Ping P Ohi Melanie D MD Gould Kathleen L KL Chazin Walter J WJ
Structure (London, England : 1993) 20100501 5
Prp19 is a member of the WD40 repeat family of E3 ubiquitin ligases and a conserved eukaryotic RNA splicing factor essential for activation and stabilization of the spliceosome. To understand the role of the WD40 repeat domain of Prp19 we have determined its structure using X-ray crystallography. The domain has a distorted seven bladed WD40 architecture with significant asymmetry due to irregular packing of blades one and seven into the core of the WD40 domain. Structure-based mutagenesis identi ...[more]