Intrinsically disordered proteins in bcl-2 regulated apoptosis.
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ABSTRACT:
SUBMITTER: Rautureau GJ
PROVIDER: S-EPMC2871139 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Publications
Intrinsically disordered proteins in bcl-2 regulated apoptosis.
Rautureau Gilles J P GJ Day Catherine L CL Hinds Mark G MG
International journal of molecular sciences 20100416 4
Intrinsic cell death is mediated by interaction between pro-apoptotic and pro-survival proteins of the B-cell lymphoma-2 (Bcl-2) family. Members of this family are either intrinsically disordered or contain intrinsically disordered regions/domains that are critical to their function. Alternate splicing and post-translational modifications can determine the extent of these disordered regions and are critical for regulating Bcl-2 proteins. Conformational plasticity and structural transitions chara ...[more]
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