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Direct determination of molecular haplotypes by chromosome microdissection.

ABSTRACT: Direct observation of haplotypes is still technically challenging. Here we report a method for the determination of haplotypes through chromosome microdissection. We determined human long-range chromosomal haplotypes with more than 98.85% accuracy at 24,245 genome-wide heterozygous single-nucleotide polymorphism (SNP) loci.

SUBMITTER: Ma L 

PROVIDER: S-EPMC2871314 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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Direct determination of molecular haplotypes by chromosome microdissection.

Ma Li L   Xiao Yan Y   Huang Hui H   Wang Qingwei Q   Rao Weinian W   Feng Yue Y   Zhang Kui K   Song Qing Q  

Nature methods 20100321 4

Direct observation of haplotypes is still technically challenging. Here we report a method for the determination of haplotypes through chromosome microdissection. We determined human long-range chromosomal haplotypes with more than 98.85% accuracy at 24,245 genome-wide heterozygous single-nucleotide polymorphism (SNP) loci. ...[more]

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