Ontology highlight
ABSTRACT:
SUBMITTER: Yanagihara I
PROVIDER: S-EPMC2871494 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Yanagihara Itaru I Nakahira Kumiko K Yamane Tsutomu T Kaieda Shuji S Mayanagi Kouta K Hamada Daizo D Fukui Takashi T Ohnishi Kiyouhisa K Kajiyama Shin'ichiro S Shimizu Toshiyuki T Sato Mamoru M Ikegami Takahisa T Ikeguchi Mitsunori M Honda Takeshi T Hashimoto Hiroshi H
The Journal of biological chemistry 20100324 21
Thermostable direct hemolysin (TDH) is a major virulence factor of Vibrio parahaemolyticus that causes pandemic foodborne enterocolitis mediated by seafood. TDH exists as a tetramer in solution, and it possesses extreme hemolytic activity. Here, we present the crystal structure of the TDH tetramer at 1.5 A resolution. The TDH tetramer forms a central pore with dimensions of 23 A in diameter and approximately 50 A in depth. Pi-cation interactions between protomers comprising the tetramer were ind ...[more]