Ontology highlight
ABSTRACT:
SUBMITTER: Emmetsberger J
PROVIDER: S-EPMC2872103 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Emmetsberger Jaime J Mirrione Martine M MM Zhou Chun C Fernandez-Monreal Monica M Siddiq Mustafa M MM Ji Kyungmin K Tsirka Stella E SE
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100501 19
Glutamatergic neurons contain free zinc packaged into neurotransmitter-loaded synaptic vesicles. Upon neuronal activation, the vesicular contents are released into the synaptic space, whereby the zinc modulates activity of postsynaptic neurons though interactions with receptors, transporters and exchangers. However, high extracellular concentrations of zinc trigger seizures and are neurotoxic if substantial amounts of zinc reenter the cells via ion channels and accumulate in the cytoplasm. Tissu ...[more]