Usefulness of Mendelian randomization in observational epidemiology.
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ABSTRACT:
SUBMITTER: Bochud M
PROVIDER: S-EPMC2872313 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Usefulness of Mendelian randomization in observational epidemiology.
Bochud Murielle M Rousson Valentin V
International journal of environmental research and public health 20100226 3
Mendelian randomization refers to the random allocation of alleles at the time of gamete formation. In observational epidemiology, this refers to the use of genetic variants to estimate a causal effect between a modifiable risk factor and an outcome of interest. In this review, we recall the principles of a "Mendelian randomization" approach in observational epidemiology, which is based on the technique of instrumental variables; we provide simulations and an example based on real data to demons ...[more]
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