Ontology highlight
ABSTRACT:
SUBMITTER: Ju R
PROVIDER: S-EPMC2872452 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Ju Rong R Cirone Pasquale P Lin Shengda S Griesbach Hilary H Slusarski Diane C DC Crews Craig M CM
Proceedings of the National Academy of Sciences of the United States of America 20100329 15
The Wnt/planar cell polarity (PCP) pathway regulates directed cell movement during development and was recently found to play a critical role in endothelial cell proliferation and angiogenesis [Zhang Y, et al. (2006) Chem Biol 13:1001-1009; Masckauchan TN, et al. (2006) Mol Biol Cell 17:5163-5172]. However, the mechanisms by which PCP signaling components regulate angiogenesis remain unknown. We report that expression of a constitutively active C-terminal domain of Dishevelled-associated activat ...[more]