Detecting gene-gene interactions that underlie human diseases.
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ABSTRACT:
SUBMITTER: Cordell HJ
PROVIDER: S-EPMC2872761 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
Detecting gene-gene interactions that underlie human diseases.
Nature reviews. Genetics 20090601 6
Following the identification of several disease-associated polymorphisms by genome-wide association (GWA) analysis, interest is now focusing on the detection of effects that, owing to their interaction with other genetic or environmental factors, might not be identified by using standard single-locus tests. In addition to increasing the power to detect associations, it is hoped that detecting interactions between loci will allow us to elucidate the biological and biochemical pathways that underp ...[more]
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