Identification of functional modules that correlate with phenotypic difference: the influence of network topology.
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ABSTRACT:
SUBMITTER: Hung JH
PROVIDER: S-EPMC2872883 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Publications
Identification of functional modules that correlate with phenotypic difference: the influence of network topology.
Hung Jui-Hung JH Hung Jui-Hung JH Whitfield Troy W TW Yang Tun-Hsiang TH Hu Zhenjun Z Weng Zhiping Z DeLisi Charles C
Genome biology 20100226 2
One of the important challenges to post-genomic biology is relating observed phenotypic alterations to the underlying collective alterations in genes. Current inferential methods, however, invariably omit large bodies of information on the relationships between genes. We present a method that takes account of such information - expressed in terms of the topology of a correlation network - and we apply the method in the context of current procedures for gene set enrichment analysis. ...[more]
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