Ontology highlight
ABSTRACT:
SUBMITTER: Boraska V
PROVIDER: S-EPMC2873325 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Boraska Vesna V Rayner Nigel W NW Groves Christopher J CJ Frayling Timothy M TM Diakite Mahamadou M Rockett Kirk A KA Kwiatkowski Dominic P DP Day-Williams Aaron G AG McCarthy Mark I MI Zeggini Eleftheria E
BMC medical genetics 20100506
<h4>Background</h4>The TNF/LTA locus has been a long-standing T2D candidate gene. Several studies have examined association of TNF/LTA SNPs with T2D but the majority have been small-scale and produced no convincing evidence of association. The purpose of this study is to examine T2D association of tag SNPs in the TNF/LTA region capturing the majority of common variation in a large-scale sample set of UK/Irish origin.<h4>Methods</h4>This study comprised a case-control (1520 cases and 2570 control ...[more]