Ontology highlight
ABSTRACT:
SUBMITTER: Carlson JC
PROVIDER: S-EPMC2873692 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Carlson Jacob C JC Li Shengying S Burr Douglas A DA Sherman David H DH
Journal of natural products 20091101 11
The novel dienoyl tetramic acids tirandamycin C (1) and tirandamycin D (2) with activity against vancomycin-resistant Enterococcus faecalis were isolated from the marine environmental isolate Streptomyces sp. 307-9, which also produces the previously identified compounds tirandamycins A (3) and B (4). Spectroscopic analysis of 1 and 2 indicated structural similarity to 3 and 4, with differences only in the pattern of pendant oxygenation on the bicyclic ketal system. The isolation of these putati ...[more]