Ontology highlight
ABSTRACT:
SUBMITTER: Orgaz JL
PROVIDER: S-EPMC2873770 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Orgaz J L JL Ladhani O O Hoek K S KS Fernández-Barral A A Mihic D D Aguilera O O Seftor E A EA Bernad A A Rodríguez-Peralto J L JL Hendrix M J C MJ Volpert O V OV Jiménez B B
Oncogene 20090921 47
Pigment epithelium-derived factor (PEDF) is a multifunctional secreted glycoprotein that displays broad anti-tumor activity based on dual targeting of the tumor microenvironment (anti-angiogenic action) and the tumor cells (direct anti-tumor action). Here, we show that PEDF expression is high in melanocytes, but it is lost during malignant progression of human melanoma. Using a high-throughput analysis of the data from microarray studies of molecular profiling of human melanoma, we found that PE ...[more]