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Symmetry-guided design and fluorous synthesis of a stable and rapidly excreted imaging tracer for (19)F MRI.

ABSTRACT: Getting FIT: A bispherical (19)F imaging tracer, (19)FIT, was designed and synthesized. (19)FIT is advantageous over perfluorocarbon-based (19)F imaging agents, as it is not retained in the organs and does not require complex formulation procedures. Imaging agents such as (19)FIT can lead to (19)F magnetic resonance imaging (MRI) playing an important role in drug therapy, analogous to the role played by (1)H MRI in disease diagnosis.

SUBMITTER: Jiang ZX 

PROVIDER: S-EPMC2873849 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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Symmetry-guided design and fluorous synthesis of a stable and rapidly excreted imaging tracer for (19)F MRI.

Jiang Zhong-Xing ZX   Liu Xin X   Jeong Eun-Kee EK   Yu Yihua Bruce YB  

Angewandte Chemie (International ed. in English) 20090101 26

Getting FIT: A bispherical (19)F imaging tracer, (19)FIT, was designed and synthesized. (19)FIT is advantageous over perfluorocarbon-based (19)F imaging agents, as it is not retained in the organs and does not require complex formulation procedures. Imaging agents such as (19)FIT can lead to (19)F magnetic resonance imaging (MRI) playing an important role in drug therapy, analogous to the role played by (1)H MRI in disease diagnosis. ...[more]

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