Ontology highlight
ABSTRACT:
SUBMITTER: Ciatto C
PROVIDER: S-EPMC2873897 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20100228 3
Vertebrate genomes encode 19 classical cadherins and about 100 nonclassical cadherins. Adhesion by classical cadherins depends on binding interactions in their N-terminal EC1 domains, which swap N-terminal beta-strands between partner molecules from apposing cells. However, strand-swapping sequence signatures are absent from nonclassical cadherins, raising the question of how these proteins function in adhesion. Here, we show that T-cadherin, a glycosylphosphatidylinositol (GPI)-anchored cadheri ...[more]