Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC2873975 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Zhang Yuan Y Doherty Tim T Li Jing J Lu Wuyuan W Barinka Cyril C Lubkowski Jacek J Hong Mei M
Journal of molecular biology 20100122 2
Human alpha-defensins [human neutrophil peptides (HNPs)] are immune defense mini-proteins that act by disrupting microbial cell membranes. Elucidating the three-dimensional (3D) structures of HNPs in lipid membranes is important for understanding their mechanisms of action. Using solid-state NMR (SSNMR), we have determined the 3D structure of HNP-1 in a microcrystalline state outside the lipid membrane, which provides benchmarks for structure determination and comparison with the membrane-bound ...[more]