Colloid formation by drugs in simulated intestinal fluid.
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ABSTRACT:
SUBMITTER: Doak AK
PROVIDER: S-EPMC2874266 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Colloid formation by drugs in simulated intestinal fluid.
Doak Allison K AK Wille Holger H Prusiner Stanley B SB Shoichet Brian K BK
Journal of medicinal chemistry 20100501 10
Many organic molecules form colloidal aggregates in aqueous solution at micromolar concentrations. These aggregates promiscuously inhibit soluble proteins and are a major source of false positives in high-throughput screening. Several drugs also form colloidal aggregates, and there has been speculation that this may affect the absorption and distribution of at least one drug in vivo. Here we investigate the ability of drugs to form aggregates in simulated intestinal fluid. Thirty-three Biopharma ...[more]
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