Ontology highlight
ABSTRACT:
SUBMITTER: Mendez MG
PROVIDER: S-EPMC2874471 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Mendez Melissa G MG Kojima Shin-Ichiro S Goldman Robert D RD
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100122 6
Vimentin is used widely as a marker of the epithelial to mesenchymal transitions (EMTs) that take place during embryogenesis and metastasis, yet the functional implications of the expression of this type III intermediate filament (IF) protein are poorly understood. Using form factor analysis and quantitative Western blotting of normal, metastatic, and vimentin-null cell lines, we show that the level of expression of vimentin IFs (VIFs) correlates with mesenchymal cell shape and motile behavior. ...[more]